The essential for the treatment of cartilage defects.


  • chondral traumatic an focal degenerative defects, e.g. osteoarthritis (Kellgren-Lawrence classification stage 1 and 2)
  • grade III and IV after Outerbridge classification
  • for cartilage defects until 10 cm2
  • recommendable for the application in the knee, femoral condyle, patella, trochlea or tibia plateau
  • can be transplanted while performing other types of surgery, such as micro-fractures, crucial ligament reconstruction, HTO, medial capsular shift and lateral release
  • cannot be used in children or patients younger than 18 years old
  • there is no age limit for the cell culture. To date, the oldest patient treated with BioSeed®-C was 72 years old at the time of transplantation.
  • There should be no previous or acute infections of the joint. The patient should not be suffering from an acute infectious disease, metabolic systemic diseases or diseases of the immune system
  • Classification according to Outerbridge

Healthy cartilage

Outerbridge grade III

Outerbridge grade IV