Conventional treatment methods and their prospects of success.

Conventional Treatment Methods

BioSeed®-C is a scientifically proven, new generation treatment of joint cartilage leasons. It combines the advantages of conventional surgical methods with the most advanced biotechnological developments. BioSeed®-C leads to new cartilaginous tissue formation and integration into the joint. The treatment with BioSeed®-C does not affect other joint areas as with mosaicplasty or endoprosthesis. Read more information about BioSeed®-C.

Microfracture / Pridie drilling / Abrasion Arthroplasty

Drilling into/milling/roughening the bone lying under the cartilage to allow stem cells to grow into the defect with the intention of stimulating cartilage formation. Repair cartilage is usually formed but, though it covers the defect, it cannot function like articular cartilage. The repair tissue is generally of poor quality and has a low mechanical load capacity. It loses its consistency and resistance at an early stage so that the patient often needs further treatment or surgery.


Removal of cartilage cylinders from a location in the joint that is subject to less strain in order to transplant them into the defect. Using this method, coverage of the defect is limited and new defects are created at the donor site.

ACI (Autologous Chondrocyte Implantation)

For many years this method was regarded as particularly promising for treating moderately severe cartilage degeneration. In this procedure, a piece of cartilage is taken from the patient (biopsy). The autologous cells are multiplied in the laboratory. After a few weeks, a suspension (fluid) containing cartilage cells is available, which is then injected into the defect in a transplant process. The cartilage defect is covered up beforehand with a periosteal patch previously taken from the shin bone.

Despite good clinical results, the ACI method also has a few drawbacks. An additional operation is required to obtain the periosteal patch, involving more pain and risk for the patient. Then the periosteal patch must be fixed by suturing to the healthy cartilage. Other disadvantages are poor mechanical stability and the problem that cartilage cells can “leak out” under the periosteal patch on the slightest exertion.